IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2(+) cancer stem cells

We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Battula, Venkata Lokesh, Nguyen, Khoa, Sun, Jeff, Pitner, Mary Kathryn, Yuan, Bin, Bartholomeusz, Chandra, Hail, Numsen, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514883/
https://ncbi.nlm.nih.gov/pubmed/28415808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16294
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados