IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2(+) cancer stem cells

We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear....

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Pubblicato in:Oncotarget
Autori principali: Battula, Venkata Lokesh, Nguyen, Khoa, Sun, Jeff, Pitner, Mary Kathryn, Yuan, Bin, Bartholomeusz, Chandra, Hail, Numsen, Andreeff, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514883/
https://ncbi.nlm.nih.gov/pubmed/28415808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16294
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