טוען...
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations
CRISPR-Cas9 has become a facile genome editing technology, yet the structural and mechanistic features underlying its function are unclear. Here, we perform extensive molecular simulations in an enhanced sampling regime, using a Gaussian-accelerated molecular dynamics (GaMD) methodology, which probe...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5514767/ https://ncbi.nlm.nih.gov/pubmed/28652374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707645114 |
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