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FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of the OSCC cell lines SCC4, SCC25, and SCC2095 with IC(50) values of 6.1, 6.3, and 4.5 μM, resp...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bai, Li-Yuan, Chiu, Chang-Fang, Chiu, Shih-Jiuan, Chu, Po-Chen, Weng, Jing-Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514089/
https://ncbi.nlm.nih.gov/pubmed/28717222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06047-9
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