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FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

In this study, we interrogated the mechanism by which the immunosuppressant FTY720 mediates anticancer effects in oral squamous cell carcinoma (OSCC) cells. FTY720 differentially suppressed the viability of the OSCC cell lines SCC4, SCC25, and SCC2095 with IC(50) values of 6.1, 6.3, and 4.5 μM, resp...

詳細記述

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書誌詳細
出版年:Sci Rep
主要な著者: Bai, Li-Yuan, Chiu, Chang-Fang, Chiu, Shih-Jiuan, Chu, Po-Chen, Weng, Jing-Ru
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514089/
https://ncbi.nlm.nih.gov/pubmed/28717222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06047-9
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