Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction

Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the I(Ks) ion channel in heart. But apart from potential I(Ks) regulation, physiological roles for AC9 are unknown. We show that loss of AC9 in mice reduces less than 3% of total AC activity in heart bu...

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Publicado en:Sci Rep
Main Authors: Li, Yong, Baldwin, Tanya A., Wang, Yan, Subramaniam, Janani, Carbajal, Anibal Garza, Brand, Cameron S., Cunha, Shane R., Dessauer, Carmen W.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514062/
https://ncbi.nlm.nih.gov/pubmed/28717248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05816-w
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