Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction

Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the I(Ks) ion channel in heart. But apart from potential I(Ks) regulation, physiological roles for AC9 are unknown. We show that loss of AC9 in mice reduces less than 3% of total AC activity in heart bu...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Li, Yong, Baldwin, Tanya A., Wang, Yan, Subramaniam, Janani, Carbajal, Anibal Garza, Brand, Cameron S., Cunha, Shane R., Dessauer, Carmen W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514062/
https://ncbi.nlm.nih.gov/pubmed/28717248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05816-w
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