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Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites

Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP), an important second messenger in cell signaling. Heterotrimeric G proteins and other regulators are important for control of AC activity. Depending on the AC isoform, Gβγ subunits can either conditionally stimulate or inhibit cAMP synthesis....

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Brand, Cameron S., Sadana, Rachna, Malik, Sundeep, Smrcka, Alan V., Dessauer, Carmen W.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576683/
https://ncbi.nlm.nih.gov/pubmed/26206488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099556
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