Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats

BACKGROUND AND PURPOSE: The PDE enzymes (PDE1–11) hydrolyse and thus inactivate cyclic nucleotides and are important in the regulation of the cardiovascular system. Here,we have investigated the effects on the cardiovascular system, of two novel selective PDE1 inhibitors, Lu AF41228 and Lu AF58027....

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Laursen, Morten, Beck, Lilliana, Kehler, Jan, Christoffersen, Claus Tornby, Bundgaard, Christoffer, Mogensen, Susie, Mow, Tomas Joachim, Pinilla, Estéfano, Knudsen, Jakob Schöllhammer, Hedegaard, Elise Røge, Grunnet, Morten, Simonsen, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513860/
https://ncbi.nlm.nih.gov/pubmed/28548283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13868
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