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Pirfenidone Is a Vasodilator: Involvement of K(V)7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice
Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Therefore, in a first study we investigated the mechan...
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| Udgivet i: | Front Pharmacol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906977/ https://ncbi.nlm.nih.gov/pubmed/33643042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.619152 |
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