PDE1A inhibition elicits cGMP‐dependent relaxation of rat mesenteric arteries

BACKGROUND AND PURPOSE: PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This study used isoform‐preferring PDE1 inhibitors, Lu AF5...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Khammy, Makhala Michell, Dalsgaard, Thomas, Larsen, Peter Hjørringgaard, Christoffersen, Claus Tornby, Clausen, Dorte, Rasmussen, Lars Kyhn, Folkersen, Lasse, Grunnet, Morten, Kehler, Jan, Aalkjær, Christian, Nielsen, Jacob
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659990/
https://ncbi.nlm.nih.gov/pubmed/28910498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14034
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