Reversible methylation of m(6)A(m) in the 5′ cap controls mRNA stability

Internal bases in mRNA can be subjected to modifications that influence the fate of mRNA in cells. One of the most prevalent modified bases is found at the 5′ end of mRNA, at the first encoded nucleotide adjacent to the 7-methylguanosine cap. Here we show that this nucleotide, N(6),2′-O-dimethyladen...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Mauer, Jan, Luo, Xiaobing, Blanjoie, Alexandre, Jiao, Xinfu, Grozhik, Anya V., Patil, Deepak P., Linder, Bastian, Pickering, Brian F., Vasseur, Jean-Jacques, Chen, Qiuying, Gross, Steven S., Elemento, Olivier, Debart, Françoise, Kiledjian, Megerditch, Jaffrey, Samie R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513158/
https://ncbi.nlm.nih.gov/pubmed/28002401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21022
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