Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

BACKGROUND: Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors have been successfully designed, no comprehensive assessment of affinity and s...

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Опубликовано в: :Proteome Sci
Главные авторы: Wong, Margaret L., Murphy, Jason, Harrington, Edmund, Gower, Carrie M., Jain, Rishi K., Schirle, Markus, Thomas, Jason R.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513037/
https://ncbi.nlm.nih.gov/pubmed/28725163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12953-017-0125-1
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