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Conformational dynamics and allostery in E2:E3 interactions drive ubiquitination: gp78 and Ube2g2
Conformational dynamics plays a fundamental role in molecular recognition and activity in enzymes. The ubiquitin-conjugating enzyme (E2) Ube2g2 functions with the ubiquitin-ligase (E3) gp78 to assemble poly-ubiquitin chains on target substrates. Two domains in gp78, RING and G2BR, bind to two distan...
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| Udgivet i: | Structure |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512444/ https://ncbi.nlm.nih.gov/pubmed/28434917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.016 |
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