Conformational Dynamics Modulate Activation of the Ubiquitin Conjugating Enzyme Ube2g2

[Image: see text] The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78 catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the proteasomal degradation of misfolded proteins in the endoplasmic reticulum. Here, we employ NMR spectroscopy in co...

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Bibliografske podrobnosti
izdano v:ACS Omega
Main Authors: Magala, Pearl, Bocik, William E., Majumdar, Ananya, Tolman, Joel R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579538/
https://ncbi.nlm.nih.gov/pubmed/28884161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00205
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