Allosteric Activation of E2-RING Finger Mediated Ubiquitylation by a Structurally-Defined Specific E2 Binding Region of gp78

The activity of RING finger ubiquitin ligases (E3) is dependent on their ability to facilitate transfer of ubiquitin from ubiquitin-conjugating enzymes (E2) to substrates. The G2BR domain within the E3 gp78 binds selectively and with high affinity to the E2 Ube2g2. Through structural and functional...

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Detalhes bibliográficos
Main Authors: Das, Ranabir, Mariano, Jennifer, Tsai, Yien Che, Kalathur, Ravi C., Kostova, Zlatka, Li, Jess, Tarasov, Sergey G., McFeeters, Robert L., Altieri, Amanda S., Ji, Xinhua, Byrd, R. Andrew, Weissman, Allan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050579/
https://ncbi.nlm.nih.gov/pubmed/19560420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.05.010
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