Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrP(Sc) can trigger pathogenic events. How levels of PrP are regulated is poor...

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Bibliografske podrobnosti
Main Authors: Shao, Jia, Choe, Vitnary, Cheng, Haili, Tsai, Yien Che, Weissman, Allan M., Luo, Shiwen, Rao, Hai
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979651/
https://ncbi.nlm.nih.gov/pubmed/24714645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092290
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