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Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation
Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrP(Sc) can trigger pathogenic events. How levels of PrP are regulated is poor...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979651/ https://ncbi.nlm.nih.gov/pubmed/24714645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092290 |
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