Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8(+) T Cell Exhaustion Marker Expression

In untreated HIV infection, CD8(+) T cell exhaustion (i.e., decreased proliferative and effector capacity) is associated with high levels of expression of coinhibitory receptors, including PD-1, T cell immunoreceptor with Ig and ITIM domains (TIGIT), CD160, and 2B4. This is evident for both HIV-spec...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Rutishauser, Rachel Lena, Hartogensis, Wendy, Deguit, Christian Deo, Krone, Melissa, Hoh, Rebecca, Hecht, Frederick M., Pilcher, Christopher D., Bacchetti, Peter, Deeks, Steven G., Hunt, Peter W., McCune, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
HIV Cure Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512309/
https://ncbi.nlm.nih.gov/pubmed/28335609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2016.0324
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