Some Aspects of CD8+ T Cell Exhaustion are Associated with Altered T Cell Mitochondrial Features and ROS content in HIV Infection

BACKGROUND: Reversing or preventing T cell exhaustion is an important treatment goal in the context of HIV disease; however, the mechanisms that regulate HIV-specific CD8+ T cell exhaustion are incompletely understood. Since mitochondrial mass (MM), mitochondrial membrane potential (MMP), and cellul...

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Vydáno v:J Acquir Immune Defic Syndr
Hlavní autoři: Deguit, Christian Deo T., Hough, Michelle, Hoh, Rebecca, Krone, Melissa, Pilcher, Christopher D., Martin, Jeffrey N., Deeks, Steven G., McCune, Joseph M., Hunt, Peter W., Rutishauser, Rachel L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746248/
https://ncbi.nlm.nih.gov/pubmed/31513075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002121
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