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Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors
[Image: see text] ERK is the effector kinase of the RAS-RAF-MEK-ERK signaling cascade, which promotes cell transformation and malignancy in many cancers and is thus a major drug target in oncology. Kinase inhibitors targeting RAF or MEK are already used for the treatment of certain cancers, such as...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2017
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512124/ https://ncbi.nlm.nih.gov/pubmed/28740606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00127 |
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