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Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK
ERK1/2 kinases are the principal effectors of a central signaling cascade that converts extracellular stimuli into cell proliferation and migration responses and, when deregulated, can promote cell oncogenic transformation. The scaffolding protein PEA-15 is a death effector domain (DED) protein that...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640864/ https://ncbi.nlm.nih.gov/pubmed/23575685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2687 |
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