Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors

[Image: see text] ERK is the effector kinase of the RAS-RAF-MEK-ERK signaling cascade, which promotes cell transformation and malignancy in many cancers and is thus a major drug target in oncology. Kinase inhibitors targeting RAF or MEK are already used for the treatment of certain cancers, such as...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Lechtenberg, Bernhard C., Mace, Peter D., Sessions, E. Hampton, Williamson, Robert, Stalder, Romain, Wallez, Yann, Roth, Gregory P., Riedl, Stefan J., Pasquale, Elena B.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512124/
https://ncbi.nlm.nih.gov/pubmed/28740606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00127
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