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Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis

DNAJB12 (JB12) is an endoplasmic reticulum (ER)–associated Hsp40 family protein that recruits Hsp70 to the ER surface to coordinate the function of ER-associated and cytosolic chaperone systems in protein quality control. Hsp70 is stress-inducible, but paradoxically, we report here that JB12 was deg...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sopha, Pattarawut, Ren, Hong Yu, Grove, Diane E., Cyr, Douglas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512073/
https://ncbi.nlm.nih.gov/pubmed/28536268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785113
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