DNA Damage Response and Repair Gene Alterations Are Associated With Improved Survival In Patients With Platinum-Treated Advanced Urothelial Carcinoma

PURPOSE: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy. EXPERIMENTAL DE...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Teo, Min Yuen, Bambury, Richard M., Zabor, Emily C., Jordan, Emmet, Al-Ahmadie, Hikmat, Boyd, Mariel E., Bouvier, Nancy, Mullane, Stephanie A., Cha, Eugene K., Roper, Nitin, Ostrovnaya, Irina, Hyman, David M., Bochner, Bernard H., Arcila, Maria E., Solit, David B., Berger, Michael F., Bajorin, Dean F., Bellmunt, Joaquim, Iyer, Gopakumar, Rosenberg, Jonathan E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511570/
https://ncbi.nlm.nih.gov/pubmed/28137924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2520
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