DNA Damage Response and Repair Gene Alterations Are Associated With Improved Survival In Patients With Platinum-Treated Advanced Urothelial Carcinoma

PURPOSE: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy. EXPERIMENTAL DE...

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Udgivet i:Clin Cancer Res
Main Authors: Teo, Min Yuen, Bambury, Richard M., Zabor, Emily C., Jordan, Emmet, Al-Ahmadie, Hikmat, Boyd, Mariel E., Bouvier, Nancy, Mullane, Stephanie A., Cha, Eugene K., Roper, Nitin, Ostrovnaya, Irina, Hyman, David M., Bochner, Bernard H., Arcila, Maria E., Solit, David B., Berger, Michael F., Bajorin, Dean F., Bellmunt, Joaquim, Iyer, Gopakumar, Rosenberg, Jonathan E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511570/
https://ncbi.nlm.nih.gov/pubmed/28137924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2520
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