Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.

Ítems similars

• Proviral-activated c-erbB is leukemogenic but not sarcomagenic: characterization of a replication-competent retrovirus containing the activated c-erbB.
  per: Pelley, R J, et al.
  Publicat: (1988)
• Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.
  per: Shu, H K, et al.
  Publicat: (1991)
• Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.
  per: Shu, H K, et al.
  Publicat: (1994)
• The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.
  per: Di Fiore, P P, et al.
  Publicat: (1990)
• c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles.
  per: Raines, M A, et al.
  Publicat: (1985)