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Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.

Avian c-erbB is activated to a leukemia oncogene following truncation of its amino-terminal, ligand-binding domain by retroviral insertion. The insertionally activated transcripts encode protein products that have constitutive tyrosine kinase activity and that can induce erythro-leukemia but not sar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shu, H K, Pelley, R J, Kung, H J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1990
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC55112/
https://ncbi.nlm.nih.gov/pubmed/1979168
Etiketak: Etiketa erantsi
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