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Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.
Avian c-erbB is activated to a leukemia oncogene following truncation of its amino-terminal ligand-binding domain by retroviral insertion. The insertionally activated transcripts encode protein products which have constitutive tyrosine kinase activity and can induce erythroleukemia but not sarcomas....
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7935404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.10.6868 |
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