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Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.

Avian c-erbB is activated to a leukemia oncogene following truncation of its amino-terminal ligand-binding domain by retroviral insertion. The insertionally activated transcripts encode protein products which have constitutive tyrosine kinase activity and can induce erythroleukemia but not sarcomas....

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Sonraí Bibleagrafaíochta
Main Authors: Shu, H K, Chang, C M, Ravi, L, Ling, L, Castellano, C M, Walter, E, Pelley, R J, Kung, H J
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1994
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC359217/
https://ncbi.nlm.nih.gov/pubmed/7935404
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