Top–down Proteomics of Large Proteins up to 223 kDa Enabled by Serial Size Exclusion Chromatography Strategy

Mass spectrometry (MS)-based top-down proteomics is a powerful method for the comprehensive analysis of proteoforms that arise from genetic variations and post-translational modifications (PTMs). However, top-down MS analysis of high molecular weight (MW) proteins remains challenging mainly due to t...

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Pubblicato in:Anal Chem
Autori principali: Cai, Wenxuan, Tucholski, Trisha, Chen, Bifan, Alpert, Andrew J., Mcilwain, Sean, Kohmoto, Takushi, Jin, Song, Ge, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511113/
https://ncbi.nlm.nih.gov/pubmed/28406609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b00380
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