Complete Characterization of Cardiac Myosin Heavy Chain (223 kDa) Enabled by Size-Exclusion Chromatography and Middle-down Mass Spectrometry

Myosin heavy chain (MHC), the major component of myosin motor molecule, plays an essential role in force production during muscle contraction. However, a comprehensive analysis of MHC proteoforms arising from sequence variations and post-translational modifications (PTMs) remains challenging due to...

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Publicado en:Anal Chem
Main Authors: Jin, Yutong, Wei, Liming, Cai, Wenxuan, Lin, Ziqing, Wu, Zhijie, Peng, Ying, Kohmoto, Takushi, Moss, Richard L., Ge, Ying
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526197/
https://ncbi.nlm.nih.gov/pubmed/28366003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b00113
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