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BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus
BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts, in the developing dentate gyrus, main...
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| Publicado en: | Stem Cell Reports |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5511112/ https://ncbi.nlm.nih.gov/pubmed/28669600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.05.030 |
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