BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

BACE1 is required for the release of β-amyloid (Aβ) in vivo, and inhibition of BACE1 activity is targeted for reducing Aβ generation in Alzheimer's patients. To further our understanding of the safe use of BACE1 inhibitors in human patients, we aimed to study the physiological functions of BACE...

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Main Authors: Hu, Xiangyou, Zhou, Xiangdong, He, Wanxia, Yang, Jun, Xiong, Wencheng, Wong, Philip, Wilson, Christopher G., Yan, Riqiang
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902368/
https://ncbi.nlm.nih.gov/pubmed/20592204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1334-10.2010
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