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BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
BACE1 is required for the release of β-amyloid (Aβ) in vivo, and inhibition of BACE1 activity is targeted for reducing Aβ generation in Alzheimer's patients. To further our understanding of the safe use of BACE1 inhibitors in human patients, we aimed to study the physiological functions of BACE...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902368/ https://ncbi.nlm.nih.gov/pubmed/20592204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1334-10.2010 |
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