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Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling
Inhibition of BACE1 is being pursued as a therapeutic target to treat patients suffering from Alzheimer’s disease because BACE1 is the sole β-secretase that generates β-amyloid peptide. Knowledge regarding other cellular functions of BACE1 is therefore critical for the safe use of BACE1 inhibitors i...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833723/ https://ncbi.nlm.nih.gov/pubmed/26465092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13395 |
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