Alternative lengthening of telomeres and ATRX/DAXX loss can reliably be detected in fine needle aspirates of pancreatic neuroendocrine tumors

PURPOSE: Pancreatic neuroendocrine tumors (PanNETs) frequently utilize the Alternative Lengthening of Telomeres (ALT) pathway for telomere maintenance. ALT is strongly correlated with ATRX and DAXX alterations and a poor prognosis in primary PanNETs. Since fine needle aspiration (FNA) is a non-invas...

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Vydáno v:Cancer
Hlavní autoři: VandenBussche, Christopher J., Allison, Derek B., Graham, Mindy K., Charu, Vivek, Lennon, Anne Marie, Wolfgang, Christopher L., Hruban, Ralph H., Heaphy, Christopher M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511056/
https://ncbi.nlm.nih.gov/pubmed/28371511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncy.21857
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