Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

PURPOSE: Pancreatic neuroendocrine tumors (PanNET) are a heterogeneous group of neoplasms with increasing incidence and unpredictable behavior. Whole-exome sequencing has identified recurrent mutations in the genes DAXX and ATRX, which correlate with loss of protein expression and alternative length...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Singhi, Aatur D., Liu, Ta-Chiang, Roncaioli, Justin L., Cao, Dengfeng, Zeh, Herbert J., Zureikat, Amer H., Tsung, Allan, Marsh, J. Wallis, Lee, Kenneth K., Hogg, Melissa E., Bahary, Nathan, Brand, Randall E., McGrath, Kevin M., Slivka, Adam, Cressman, Kristi L., Fuhrer, Kimberly, O’Sullivan, Roderick J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560642/
https://ncbi.nlm.nih.gov/pubmed/27407094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1113
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