A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

The Janus kinases (Jaks) are hubs in the signaling process of more than 50 cytokine or hormone receptors. However, the function of Jak in bone metabolism remains to be elucidated. Here, we showed that the inhibition of Jak1 and/or Jak2 in osteoblast-lineage cells led to impaired osteoclastogenesis d...

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Veröffentlicht in:PLoS One
Hauptverfasser: Murakami, Kohei, Kobayashi, Yasuhiro, Uehara, Shunsuke, Suzuki, Takako, Koide, Masanori, Yamashita, Teruhito, Nakamura, Midori, Takahashi, Naoyuki, Kato, Hiroyuki, Udagawa, Nobuyuki, Nakamura, Yukio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510865/
https://ncbi.nlm.nih.gov/pubmed/28708884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181126
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