A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

The Janus kinases (Jaks) are hubs in the signaling process of more than 50 cytokine or hormone receptors. However, the function of Jak in bone metabolism remains to be elucidated. Here, we showed that the inhibition of Jak1 and/or Jak2 in osteoblast-lineage cells led to impaired osteoclastogenesis d...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Murakami, Kohei, Kobayashi, Yasuhiro, Uehara, Shunsuke, Suzuki, Takako, Koide, Masanori, Yamashita, Teruhito, Nakamura, Midori, Takahashi, Naoyuki, Kato, Hiroyuki, Udagawa, Nobuyuki, Nakamura, Yukio
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510865/
https://ncbi.nlm.nih.gov/pubmed/28708884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181126
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