Sclerostin expression in trabecular bone is downregulated by osteoclasts

Bone tissues have trabecular bone with a high bone turnover and cortical bone with a low turnover. The mechanisms by which the turnover rate of these bone tissues is determined remain unclear. Osteocytes secrete sclerostin, a Wnt/β-catenin signaling antagonist, and inhibit bone formation. We found t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koide, Masanori, Yamashita, Teruhito, Murakami, Kohei, Uehara, Shunsuke, Nakamura, Keigo, Nakamura, Midori, Matsushita, Mai, Ara, Toshiaki, Yasuda, Hisataka, Penninger, Josef M., Takahashi, Naoyuki, Udagawa, Nobuyuki, Kobayashi, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426814/
https://ncbi.nlm.nih.gov/pubmed/32792620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70817-1
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