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Positive and Negative Regulators of Sclerostin Expression
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negativ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2022-04-01
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| Colecção: | International Journal of Molecular Sciences |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1422-0067/23/9/4895 |
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