Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis

Osteoblasts express two key molecules for osteoclast differentiation, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG), a soluble decoy receptor for RANKL. RANKL induces osteoclastogenesis, while OPG inhibits it by blocking the binding of RANKL to RANK, a cellular receptor of RAN...

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Udgivet i:PLoS One
Main Authors: Ozaki, Yuki, Koide, Masanori, Furuya, Yuriko, Ninomiya, Tadashi, Yasuda, Hisataka, Nakamura, Midori, Kobayashi, Yasuhiro, Takahashi, Naoyuki, Yoshinari, Nobuo, Udagawa, Nobuyuki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609750/
https://ncbi.nlm.nih.gov/pubmed/28937990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184904
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