Arctigenin Inhibits Osteoclast Differentiation and Function by Suppressing Both Calcineurin-Dependent and Osteoblastic Cell-Dependent NFATc1 Pathways

Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibited the action of nuclear factor of activated T-cel...

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Autors principals: Yamashita, Teruhito, Uehara, Shunsuke, Udagawa, Nobuyuki, Li, Feng, Kadota, Shigetoshi, Esumi, Hiroyasu, Kobayashi, Yasuhiro, Takahashi, Naoyuki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895012/
https://ncbi.nlm.nih.gov/pubmed/24465763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085878
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