Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice

Leukocyte adhesion to P-selectin on activated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulation. Plasma soluble P-selectin (sP-selectin) is elevated threefold to fourfold in patients with cardiovascular disease. Circulating sP-selectin is thought to t...

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Udgivet i:Blood
Main Authors: Panicker, Sumith R., Mehta-D’souza, Padmaja, Zhang, Nan, Klopocki, Arkadiusz G., Shao, Bojing, McEver, Rodger P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Phagocytes, Granulocytes, and Myelopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510792/
https://ncbi.nlm.nih.gov/pubmed/28515093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-770479
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