Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T(FH)) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repress...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Park, Sungjun, Lee, Seungwon, Lee, Choong-Gu, Park, Guk Yeol, Hong, Hyebeen, Lee, Jeon-Soo, Kim, Young Min, Lee, Sung Bae, Hwang, Daehee, Choi, Youn Soo, Fryer, John D., Im, Sin-Hyeog, Lee, Seung-Woo, Lee, Yoontae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510180/
https://ncbi.nlm.nih.gov/pubmed/28855737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16037
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