Deficiency of Capicua disrupts bile acid homeostasis

Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction...

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發表在:Sci Rep
Main Authors: Kim, Eunjeong, Park, Sungjun, Choi, Nahyun, Lee, Jieon, Yoe, Jeehyun, Kim, Soeun, Jung, Hoe-Yune, Kim, Kyong-Tai, Kang, Hyojin, Fryer, John D., Zoghbi, Huda Y., Hwang, Daehee, Lee, Yoontae
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317698/
https://ncbi.nlm.nih.gov/pubmed/25653040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08272
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