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Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). To determine the long-term effects of exercise, we implemented a mild exercise regimen in a mouse model of SCA1 and found a considerable improvement in surviv...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232424/ https://ncbi.nlm.nih.gov/pubmed/22053053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1212673 |
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