Population pharmacokinetics and pharmacodynamics of linezolid‐induced thrombocytopenia in hospitalized patients

AIMS: Thrombocytopenia is among the most important adverse effects of linezolid treatment. Linezolid‐induced thrombocytopenia incidence varies considerably but has been associated with impaired renal function. We investigated the pharmacodynamic mechanism (myelosuppression or enhanced platelet destr...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Tsuji, Yasuhiro, Holford, Nicholas H.G., Kasai, Hidefumi, Ogami, Chika, Heo, Young‐A, Higashi, Yoshitsugu, Mizoguchi, Akiko, To, Hideto, Yamamoto, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510085/
https://ncbi.nlm.nih.gov/pubmed/28186644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13262
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