Population pharmacokinetic and pharmacodynamic modelling of the effects of nicorandil in the treatment of acute heart failure

AIMS: The aims of the study were 1) to evaluate the pharmacokinetics of nicorandil in healthy subjects and acute heart failure (AHF) patients and 2) to evaluate the exposure-response relationship with pulmonary arterial wedge pressure (PAWP) in AHF patients and to predict an appropriate dosing regim...

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Autors principals: Iida, Satofumi, Kinoshita, Haruki, Holford, Nicholas H G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2008
Matèries:
Pharmacokinetic Dynamic Relationships
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526243/
https://ncbi.nlm.nih.gov/pubmed/18782142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03257.x
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