Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorders. The recognition of perturbed lipid metabolism is only rece...

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Udgivet i:Sci Rep
Main Authors: Di Pardo, Alba, Amico, Enrico, Basit, Abdul, Armirotti, Andrea, Joshi, Piyush, Neely, M. Diana, Vuono, Romina, Castaldo, Salvatore, Digilio, Anna F., Scalabrì, Francesco, Pepe, Giuseppe, Elifani, Francesca, Madonna, Michele, Jeong, Se Kyoo, Park, Bu-Mahn, D’Esposito, Maurizio, Bowman, Aaron B., Barker, Roger A., Maglione, Vittorio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509685/
https://ncbi.nlm.nih.gov/pubmed/28706199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05709-y
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