ABCB1 Genotype is Associated with Fentanyl Requirements in Critically Ill Children

BACKGROUND: The gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children. METHODS:...

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Gepubliceerd in:Pediatr Res
Hoofdauteurs: Horvat, Christopher M., Au, Alicia K., Conley, Yvette L., Kochanek, Patrick M., Li, Lingjue, Poloyac, Samuel L., Empey, Philip E., Clark, Robert S. B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509475/
https://ncbi.nlm.nih.gov/pubmed/28388599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.103
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