ABCB1 Genotype is Associated with Fentanyl Requirements in Critically Ill Children

BACKGROUND: The gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children. METHODS:...

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發表在:Pediatr Res
Main Authors: Horvat, Christopher M., Au, Alicia K., Conley, Yvette L., Kochanek, Patrick M., Li, Lingjue, Poloyac, Samuel L., Empey, Philip E., Clark, Robert S. B.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509475/
https://ncbi.nlm.nih.gov/pubmed/28388599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.103
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