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Spiral architecture of the Hsp104 disaggregase reveals the structural basis for polypeptide translocation
ClpB and Hsp104 are conserved AAA+ protein disaggregases that promote survival during cellular stress. Hsp104 acts on amyloids, supporting prion propagation in yeast, and can solubilize toxic oligomers connected to neurodegenerative diseases. A definitive structural mechanism, however, has remained...
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| 發表在: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509435/ https://ncbi.nlm.nih.gov/pubmed/27478928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3277 |
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