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m(6)A RNA methylation promotes XIST-mediated transcriptional repression
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that in human cells XIST is highly methylated with at least 78 N(6)-methyladenosine (m(6)A) residues—a reversible base modification of unknown function in l...
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| Publicado no: | Nature |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509218/ https://ncbi.nlm.nih.gov/pubmed/27602518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19342 |
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