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Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases

IMPORTANCE: Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies. OBJECTIVE: To determine whether there are intrinsic subtype difference...

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Bibliographische Detailangaben
Veröffentlicht in:JAMA Oncol
Hauptverfasser: Priedigkeit, Nolan, Hartmaier, Ryan J., Chen, Yijing, Vareslija, Damir, Basudan, Ahmed, Watters, Rebecca J., Thomas, Roby, Leone, Jose P., Lucas, Peter C., Bhargava, Rohit, Hamilton, Ronald L., Chmielecki, Juliann, Puhalla, Shannon L., Davidson, Nancy E., Oesterreich, Steffi, Brufsky, Adam M., Young, Leonie, Lee, Adrian V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508875/
https://ncbi.nlm.nih.gov/pubmed/27926948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.5630
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